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-Structure paper
Title | Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 904-907, Year 2009 |
Publish date | Dec 18, 2008 (structure data deposition date) |
Authors | Flatt, B. / Martin, R. / Wang, T.L. / Mahaney, P. / Murphy, B. / Gu, X.H. / Foster, P. / Li, J. / Pircher, P. / Petrowski, M. ...Flatt, B. / Martin, R. / Wang, T.L. / Mahaney, P. / Murphy, B. / Gu, X.H. / Foster, P. / Li, J. / Pircher, P. / Petrowski, M. / Schulman, I. / Westin, S. / Wrobel, J. / Yan, G. / Bischoff, E. / Daige, C. / Mohan, R. |
External links | J. Med. Chem. / PubMed:19159286 |
Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | PDB-3fli: |
Chemicals | ChemComp-33Y: ChemComp-HOH: |
Source |
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Keywords | TRANSCRIPTION / FXR / BAR / NR1H4 / BILE ACID RECEPTOR / NUCLEAR RECEPTOR / LIGAND-BINDING DOMAIN / ALPHA-HELICAL SANDWICH / TRANSCRIPTIONAL REGULATOR / DNA-BINDING / METAL-BINDING / NUCLEUS / REPRESSOR / Activator / Alternative splicing / Receptor / Transcription regulation / Zinc / Zinc-finger |