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TitleDesign and biological evaluation of novel, balanced dual PPARalpha/gamma agonists
Journal, issue, pagesChemmedchem, Vol. 4, Page 951-956, Year 2009
Publish dateNov 30, 2008 (structure data deposition date)
AuthorsGrether, U. / Benardeau, A. / Benz, J. / Binggeli, A. / Blum, D. / Hilpert, H. / Kuhn, B. / Maerki, H.P. / Meyer, M. / Mohr, P. ...Grether, U. / Benardeau, A. / Benz, J. / Binggeli, A. / Blum, D. / Hilpert, H. / Kuhn, B. / Maerki, H.P. / Meyer, M. / Mohr, P. / Puntener, K. / Raab, S. / Ruf, A. / Schlatter, D.
External linksChemmedchem / PubMed:19326383
MethodsX-ray diffraction
Resolution2.01 - 2.4 Å
Structure data

PDB-3fei:
Design and biological evaluation of novel, balanced dual PPARa/g agonists
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3fej:
Design and biological evaluation of novel, balanced dual PPARa/g agonists
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

Chemicals

ChemComp-CTM:
(2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / NUCLEAR RECEPTOR / TRANSCRIPTION FACTOR / DIABETES / Activator / DNA-binding / Metal-binding / Nucleus / Polymorphism / Receptor / Transcription regulation / Zinc / Zinc-finger / Nuclear Recpetor / Alternative splicing / Diabetes mellitus / Disease mutation / Obesity / Phosphoprotein

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