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TitleHigh-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 48, Page 4318-4322, Year 2009
Publish dateNov 26, 2008 (structure data deposition date)
AuthorsLee, E.F. / Sadowsky, J.D. / Smith, B.J. / Czabotar, P.E. / Peterson-Kaufman, K.J. / Colman, P.M. / Gellman, S.H. / Fairlie, W.D.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:19229915
MethodsX-ray diffraction
Resolution1.78 - 2.26 Å
Structure data

PDB-3fdl:
Bim BH3 peptide in complex with Bcl-xL
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-3fdm:
alpha/beta foldamer in complex with Bcl-xL
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsAPOPTOSIS / helical bundle / peptide-protein complex / Alternative splicing / Membrane / Mitochondrion / Nucleus / Transmembrane / Phosphoprotein / protein-peptide complex / foldamer

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