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TitleOptimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 1446-1450, Year 2009
Publish dateNov 21, 2008 (structure data deposition date)
AuthorsMcMinn, D.L. / Rew, Y. / Sudom, A. / Caille, S. / Degraffenreid, M. / He, X. / Hungate, R. / Jiang, B. / Jaen, J. / Julian, L.D. ...McMinn, D.L. / Rew, Y. / Sudom, A. / Caille, S. / Degraffenreid, M. / He, X. / Hungate, R. / Jiang, B. / Jaen, J. / Julian, L.D. / Kaizerman, J. / Novak, P. / Sun, D. / Tu, H. / Ursu, S. / Walker, N.P. / Yan, X. / Ye, Q. / Wang, Z. / Powers, J.P.
External linksBioorg. Med. Chem. Lett. / PubMed:19185488
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-3fco:
Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Benzamide Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-IIG:
N-cyclopropyl-N-(cis-4-cyclopropyl-4-hydroxycyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Endoplasmic reticulum / Glycoprotein / Lipid metabolism / Membrane / NADP / Polymorphism / Signal-anchor / Steroid metabolism / Transmembrane

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