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-Structure paper
| Title | Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. |
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| Journal, issue, pages | J. Med. Chem., Vol. 51, Page 5758-5765, Year 2008 |
| Publish date | Nov 17, 2008 (structure data deposition date) |
 Authors | Chao, E.Y. / Caravella, J.A. / Watson, M.A. / Campobasso, N. / Ghisletti, S. / Billin, A.N. / Galardi, C. / Wang, P. / Laffitte, B.A. / Iannone, M.A. ...Chao, E.Y. / Caravella, J.A. / Watson, M.A. / Campobasso, N. / Ghisletti, S. / Billin, A.N. / Galardi, C. / Wang, P. / Laffitte, B.A. / Iannone, M.A. / Goodwin, B.J. / Nichols, J.A. / Parks, D.J. / Stewart, E. / Wiethe, R.W. / Williams, S.P. / Smallwood, A. / Pearce, K.H. / Glass, C.K. / Willson, T.M. / Zuercher, W.J. / Collins, J.L. |
 External links | J. Med. Chem. / PubMed:18800767 |
| Methods | X-ray diffraction |
| Resolution | 2.36 Å |
| Structure data |  PDB-3fal: |
| Chemicals |  ChemComp-REA:  ChemComp-LO2:  ChemComp-HOH: |
| Source |
|
 Keywords | SIGNALING PROTEIN / Nuclear hormone receptor nonsteroidal LXR agonist choloestorol metabolism / DNA-binding / Host-virus interaction / Metal-binding / Nucleus / Polymorphism / Receptor / Transcription / Transcription regulation / Ubl conjugation / Zinc / Zinc-finger |
homo sapiens (human)
mus musculus (house mouse)