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-Structure paper
Title | Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 17, Page 2017-2029, Year 2009 |
Publish date | Nov 10, 2008 (structure data deposition date) |
Authors | Saitoh, M. / Kunitomo, J. / Kimura, E. / Hayase, Y. / Kobayashi, H. / Uchiyama, N. / Kawamoto, T. / Tanaka, T. / Mol, C.D. / Dougan, D.R. ...Saitoh, M. / Kunitomo, J. / Kimura, E. / Hayase, Y. / Kobayashi, H. / Uchiyama, N. / Kawamoto, T. / Tanaka, T. / Mol, C.D. / Dougan, D.R. / Textor, G.S. / Snell, G.P. / Itoh, F. |
External links | Bioorg. Med. Chem. / PubMed:19200745 |
Methods | X-ray diffraction |
Resolution | 2.4 - 2.6 Å |
Structure data | PDB-3f7z: PDB-3f88: |
Chemicals | ChemComp-34O: ChemComp-HOH: ChemComp-3HT: ChemComp-2HT: |
Source |
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Keywords | TRANSFERASE / enzyme / protein kinase / inhibitor co-crystal structure / ATP-binding / Kinase / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase / Wnt signaling pathway / inhibitor / Alternative splicing |