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Structure paper

TitleCrystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems.
Journal, issue, pagesFaseb J., Vol. 23, Page 2735-2740, Year 2009
Publish dateNov 7, 2008 (structure data deposition date)
AuthorsZhang, H. / Astrof, N.S. / Liu, J.H. / Wang, J.H. / Shimaoka, M.
External linksFaseb J. / PubMed:19332643
MethodsX-ray diffraction
Resolution1.6 - 1.7 Å
Structure data

PDB-3f74:
Crystal structure of wild type LFA1 I domain
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-3f78:
Crystal structure of wild type LFA1 I domain complexed with isoflurane
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ICF:
1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER / medication*YM

Source
  • homo sapiens (human)
KeywordsCELL ADHESION / integrin / LFA1 / I domain / inactive conformation / wild type / Glycoprotein / Magnesium / Membrane / Receptor / Transmembrane / volatile anesthetic / isoflurane / inhibitor of integrin

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