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TitleTuning a three-component reaction for trapping kinase substrate complexes.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 130, Page 17568-17574, Year 2008
Publish dateNov 6, 2008 (structure data deposition date)
AuthorsStatsuk, A.V. / Maly, D.J. / Seeliger, M.A. / Fabian, M.A. / Biggs, W.H. / Lockhart, D.J. / Zarrinkar, P.P. / Kuriyan, J. / Shokat, K.M.
External linksJ. Am. Chem. Soc. / PubMed:19053485
MethodsX-ray diffraction
Resolution2.35 Å
Structure data

PDB-3f6x:
c-Src kinase domain in complex with small molecule inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-IHH:
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile

ChemComp-HOH:
WATER

Source
  • gallus gallus (chicken)
KeywordsTRANSFERASE / Kinase / ATP-Binding / Alternative splicing / Lipoprotein / Myristate / Nucleotide-binding / Phosphoprotein / Proto-oncogene / SH2 domain / SH3 domain / Tyrosine-protein kinase

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