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-Structure paper
Title | Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 1814-1827, Year 2009 |
Publish date | Oct 29, 2008 (structure data deposition date) |
Authors | Qian, K. / Wang, L. / Cywin, C.L. / Farmer, B.T. / Hickey, E. / Homon, C. / Jakes, S. / Kashem, M.A. / Lee, G. / Leonard, S. ...Qian, K. / Wang, L. / Cywin, C.L. / Farmer, B.T. / Hickey, E. / Homon, C. / Jakes, S. / Kashem, M.A. / Lee, G. / Leonard, S. / Li, J. / Magboo, R. / Mao, W. / Pack, E. / Peng, C. / Prokopowicz, A. / Welzel, M. / Wolak, J. / Morwick, T. |
External links | J. Med. Chem. / PubMed:19256503 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-3f2a: |
Chemicals | ChemComp-985: ChemComp-MG: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / potein kinase fold / Alternative initiation / ATP-binding / Cell membrane / Cytoplasm / Kinase / Manganese / Membrane / Metal-binding / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism / Proto-oncogene / Serine/threonine-protein kinase |