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-Structure paper
Title | Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 54-57, Year 2009 |
Publish date | Oct 15, 2008 (structure data deposition date) |
![]() | Guo, Z. / Orth, P. / Wong, S.C. / Lavey, B.J. / Shih, N.Y. / Niu, X. / Lundell, D.J. / Madison, V. / Kozlowski, J.A. |
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Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | ![]() PDB-3ewj: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-INN: ![]() ChemComp-642: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / TACE / ADAM17 / Cleavage on pair of basic residues / Glycoprotein / Membrane / Metal-binding / Metalloprotease / Notch signaling pathway / Phosphoprotein / Protease / SH3-binding / Transmembrane / Zymogen |