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Structure paper

TitleStructural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases.
Journal, issue, pagesBiochemistry, Vol. 48, Page 9618-9626, Year 2009
Publish dateOct 14, 2008 (structure data deposition date)
AuthorsHo, M.C. / Cassera, M.B. / Madrid, D.C. / Ting, L.M. / Tyler, P.C. / Kim, K. / Almo, S.C. / Schramm, V.L.
External linksBiochemistry / PubMed:19728741
MethodsX-ray diffraction
Resolution1.9 - 2.11 Å
Structure data

PDB-3ewc:
Crystal Structure of adenosine deaminase from Plasmodial vivax in complex with MT-coformycin
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

PDB-3ewd:
Crystal structure of adenosine deaminase mutant (delta Asp172) from Plasmodium vivax in complex with MT-coformycin
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MCF:
(8R)-3-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol

ChemComp-HOH:
WATER

Source
  • plasmodium vivax (malaria parasite P. vivax)
KeywordsHYDROLASE / adenosine deaminase / MT-coformycin / methylthio-coformycin

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