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TitleStructure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
Journal, issue, pagesBlood, Vol. 113, Page 4381-4390, Year 2009
Publish dateOct 8, 2008 (structure data deposition date)
AuthorsGordon, W.R. / Roy, M. / Vardar-Ulu, D. / Garfinkel, M. / Mansour, M.R. / Aster, J.C. / Blacklow, S.C.
External linksBlood / PubMed:19075186
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3eto:
2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / alpha-beta sandwich / HD domain / LNR repeat / calcium-binding / SEA domain / autoinhibition / Activator / T-ALL / leukemia / oncogene / ANK repeat / Developmental protein / Differentiation / EGF-like domain / Glycoprotein / Membrane / Metal-binding / Notch signaling pathway / Nucleus / Phosphoprotein / Receptor / Transcription / Transcription regulation / Transmembrane

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