Movie
Controller
Structure viewers
About Yorodumi Papers
+Search query
-Structure paper
| Title | 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase). |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 6171-6174, Year 2008 |
| Publish date | Sep 30, 2008 (structure data deposition date) |
 Authors | Warmus, J.S. / Flamme, C. / Zhang, L.Y. / Barrett, S. / Bridges, A. / Chen, H. / Gowan, R. / Kaufman, M. / Sebolt-Leopold, J. / Leopold, W. ...Warmus, J.S. / Flamme, C. / Zhang, L.Y. / Barrett, S. / Bridges, A. / Chen, H. / Gowan, R. / Kaufman, M. / Sebolt-Leopold, J. / Leopold, W. / Merriman, R. / Ohren, J. / Pavlovsky, A. / Przybranowski, S. / Tecle, H. / Valik, H. / Whitehead, C. / Zhang, E. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:18951019 |
| Methods | X-ray diffraction |
| Resolution | 2.62 Å |
| Structure data |  PDB-3eqb: |
| Chemicals |  ChemComp-ATP:  ChemComp-MG:  ChemComp-LUG:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE / PROTEIN KINASE STRUCTURE / MITOGEN ACTIVATED PROTEIN KINASE KINASE / SIGNAL TRANSDUCTION / LIGAND CO-COMPLEX / TERNARY CO-COMPLEX WITH KINASE / LIGAND AND MGATP / NON-COMPETITIVE PROTEIN KINASE INHIBITOR / Acetylation / ATP-binding / Disease mutation / Kinase / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase / Tyrosine-protein kinase |
homo sapiens (human)