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TitleDiscovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 6231-6235, Year 2008
Publish dateSep 24, 2008 (structure data deposition date)
AuthorsFarmer, L.J. / Bemis, G. / Britt, S.D. / Cochran, J. / Connors, M. / Harrington, E.M. / Hoock, T. / Markland, W. / Nanthakumar, S. / Taslimi, P. ...Farmer, L.J. / Bemis, G. / Britt, S.D. / Cochran, J. / Connors, M. / Harrington, E.M. / Hoock, T. / Markland, W. / Nanthakumar, S. / Taslimi, P. / Ter Haar, E. / Wang, J. / Zhaveri, D. / Salituro, F.G.
External linksBioorg. Med. Chem. Lett. / PubMed:18938080
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-3emg:
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-685:
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase / syk / Alternative splicing / ATP-binding / Host-virus interaction / Nucleotide-binding / Phosphoprotein / Polymorphism / SH2 domain / Tyrosine-protein kinase / Ubl conjugation

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