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Structure paper

TitleSynthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 5758-5762, Year 2008
Publish dateSep 15, 2008 (structure data deposition date)
AuthorsStevens, K.L. / Reno, M.J. / Alberti, J.B. / Price, D.J. / Kane-Carson, L.S. / Knick, V.B. / Shewchuk, L.M. / Hassell, A.M. / Veal, J.M. / Davis, S.T. ...Stevens, K.L. / Reno, M.J. / Alberti, J.B. / Price, D.J. / Kane-Carson, L.S. / Knick, V.B. / Shewchuk, L.M. / Hassell, A.M. / Veal, J.M. / Davis, S.T. / Griffin, R.J. / Peel, M.R.
External linksBioorg. Med. Chem. Lett. / PubMed:18835709
MethodsX-ray diffraction
Resolution3.15 - 3.22 Å
Structure data

PDB-3eid:
CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

PDB-3ej1:
CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.22 Å

Chemicals

ChemComp-PO5:
(2S)-1-(dimethylamino)-3-(4-{[4-(6-morpholin-4-ylpyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl]amino}phenoxy)propan-2-ol

ChemComp-HOH:
WATER

ChemComp-5BP:
N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine

Source
  • homo sapiens (human)
KeywordsTransferase/Cell Cycle / cdk2 / cyclin / ATP-binding / Cell cycle / Cell division / Kinase / Mitosis / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase / Transferase / Nucleus / Transferase-Cell Cycle COMPLEX / cdk

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