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Structure paper

TitleKinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Journal, issue, pagesBiochemistry, Vol. 47, Page 12760-12768, Year 2008
Publish dateSep 1, 2008 (structure data deposition date)
AuthorsWang, H. / Yan, Z. / Yang, S. / Cai, J. / Robinson, H. / Ke, H.
External linksBiochemistry / PubMed:18983167
MethodsX-ray diffraction
Resolution1.9 - 2.1 Å
Structure data

PDB-3ecm:
Crystal structure of the unliganded PDE8A catalytic domain
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3ecn:
Crystal structure of PDE8A catalytic domain in complex with IBMX
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-IBM:
3-ISOBUTYL-1-METHYLXANTHINE / inhibitor, antagonist*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Phosphodiesterase 8A PDE8A inhibitor selectivity / Alternative splicing / cAMP / Magnesium / Manganese / Metal-binding / IBMX / PDE8A catalytic domain / refolding

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