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TitleCortisone dissociates the Shaker family K+ channels from their beta subunits.
Journal, issue, pagesNat. Chem. Biol., Vol. 4, Page 708-714, Year 2008
Publish dateAug 26, 2008 (structure data deposition date)
AuthorsPan, Y. / Weng, J. / Kabaleeswaran, V. / Li, H. / Cao, Y. / Bhosle, R.C. / Zhou, M.
External linksNat. Chem. Biol. / PubMed:18806782
MethodsX-ray diffraction
Resolution1.82 - 2 Å
Structure data

PDB-3eau:
Voltage-dependent K+ channel beta subunit in complex with cortisone
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-3eb3:
Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3eb4:
Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-PDN:
17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE / medication*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsTRANSPORT PROTEIN / oxidoreductase / Kvbeta / cortisone / NADPH / Cytoplasm / Ion transport / Ionic channel / NADP / Phosphoprotein / Potassium / Potassium transport / Transport / Voltage-gated channel / interface

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