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-Structure paper
Title | Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. |
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Journal, issue, pages | Protein Sci., Vol. 17, Page 1791-1797, Year 2008 |
Publish date | Aug 13, 2008 (structure data deposition date) |
Authors | Zhao, B. / Smallwood, A. / Yang, J. / Koretke, K. / Nurse, K. / Calamari, A. / Kirkpatrick, R.B. / Lai, Z. |
External links | Protein Sci. / PubMed:18662907 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-3e5a: |
Chemicals | ChemComp-VX6: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / AURORA A / SERINE/THREONINE-PROTEIN KINASE / COFACTOR / TPX2 / VX-680 / INHIBITOR / PHOSPHORYLATION / ATP-binding / Cell cycle / Nucleotide-binding / Phosphoprotein / Nucleus |