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-Structure paper
Title | Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 5895-5899, Year 2008 |
Publish date | Jul 31, 2008 (structure data deposition date) |
![]() | Tully, D.C. / Vidal, A. / Chatterjee, A.K. / Williams, J.A. / Roberts, M.J. / Petrassi, H.M. / Spraggon, G. / Bursulaya, B. / Pacoma, R. / Shipway, A. ...Tully, D.C. / Vidal, A. / Chatterjee, A.K. / Williams, J.A. / Roberts, M.J. / Petrassi, H.M. / Spraggon, G. / Bursulaya, B. / Pacoma, R. / Shipway, A. / Schumacher, A.M. / Danahay, H. / Harris, J.L. |
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Methods | X-ray diffraction |
Resolution | 1.6 - 1.7 Å |
Structure data | ![]() PDB-3e0p: ![]() PDB-3e16: |
Chemicals | ![]() ChemComp-B3C: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-B4C: ![]() ChemComp-DMS: |
Source |
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![]() | HYDROLASE / PROSTASIN / PROTEASE / benzoxazole / warhead / Channel / ENaC / Cell membrane / Glycoprotein / Membrane / Secreted / Serine protease / Transmembrane / Zymogen / HCAP-1 / Channel Activating Protease / inhibitor |