+Search query
-Structure paper
Title | SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. |
---|---|
Journal, issue, pages | Mol. Cancer Ther., Vol. 8, Page 3181-3190, Year 2009 |
Publish date | Jun 24, 2008 (structure data deposition date) |
Authors | Buchanan, S.G. / Hendle, J. / Lee, P.S. / Smith, C.R. / Bounaud, P.Y. / Jessen, K.A. / Tang, C.M. / Huser, N.H. / Felce, J.D. / Froning, K.J. ...Buchanan, S.G. / Hendle, J. / Lee, P.S. / Smith, C.R. / Bounaud, P.Y. / Jessen, K.A. / Tang, C.M. / Huser, N.H. / Felce, J.D. / Froning, K.J. / Peterman, M.C. / Aubol, B.E. / Gessert, S.F. / Sauder, J.M. / Schwinn, K.D. / Russell, M. / Rooney, I.A. / Adams, J. / Leon, B.C. / Do, T.H. / Blaney, J.M. / Sprengeler, P.A. / Thompson, D.A. / Smyth, L. / Pelletier, L.A. / Atwell, S. / Holme, K. / Wasserman, S.R. / Emtage, S. / Burley, S.K. / Reich, S.H. |
External links | Mol. Cancer Ther. / PubMed:19934279 |
Methods | X-ray diffraction |
Resolution | 1.52 - 1.91 Å |
Structure data | PDB-3dkc: PDB-3dkf: PDB-3dkg: |
Chemicals | ChemComp-MG: ChemComp-CL: ChemComp-ATP: ChemComp-HOH: ChemComp-SX8: |
Source |
|
Keywords | ONCOPROTEIN / DRUG DISCOVERY / c-MET KINASE / FRAGMENT BASED / Membrane / Receptor / Transmembrane |