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Title4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 4482-4485, Year 2008
Publish dateJun 4, 2008 (structure data deposition date)
AuthorsShafer, C.M. / Lindvall, M. / Bellamacina, C. / Gesner, T.G. / Yabannavar, A. / Jia, W. / Lin, S. / Walter, A.
External linksBioorg. Med. Chem. Lett. / PubMed:18672368
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-3dcv:
Crystal structure of human Pim1 kinase complexed with 4-(4-hydroxy-3-methyl-phenyl)-6-phenylpyrimidin-2(1H)-one
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-55E:
4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Ser/Thr protein kinase / nucleotide-binding / phsphorylation / ATP-binding / cancer / oncogene / Alternative initiation / Cytoplasm / Manganese / Membrane / Metal-binding / Nucleus / Phosphoprotein / Polymorphism / Proto-oncogene / Serine/threonine-protein kinase

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