+Search query
-Structure paper
Title | X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. |
---|---|
Journal, issue, pages | J. Struct. Biol., Vol. 166, Page 162-171, Year 2009 |
Publish date | May 30, 2008 (structure data deposition date) |
![]() | Bennett, B.C. / Wan, Q. / Ahmad, M.F. / Langan, P. / Dealwis, C.G. |
![]() | ![]() |
Methods | X-ray diffraction |
Resolution | 1.5 - 2.3 Å |
Structure data | ![]() PDB-3dat: ![]() PDB-3dau: |
Chemicals | ![]() ChemComp-MTX: ![]() ChemComp-NDP: ![]() ChemComp-HOH: |
Source |
|
![]() | OXIDOREDUCTASE / dual-site inhibition / pseudo-Rossmann fold / adenine nucleotide binding domain / Antibiotic resistance / Methotrexate resistance / NADP / One-carbon metabolism / Trimethoprim resistance |