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TitleSeleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 130, Page 13196-13197, Year 2008
Publish dateMay 27, 2008 (structure data deposition date)
AuthorsAbdo, M. / Liu, S. / Zhou, B. / Walls, C.D. / Wu, L. / Knapp, S. / Zhang, Z.Y.
External linksJ. Am. Chem. Soc. / PubMed:18781746
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3d9c:
Crystal Structure PTP1B complex with aryl Seleninic acid
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ZYZ:
(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / inhibitor / covalent bond / Acetylation / Endoplasmic reticulum / Membrane / Oxidation / Phosphoprotein / Polymorphism / Protein phosphatase

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