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TitleMet909 plays a key role in the activation of the progesterone receptor and also in the high potency of 13-ethyl progestins
Journal, issue, pagesMol. Pharmacol., Vol. 75, Page 1317-1324, Year 2009
Publish dateMay 26, 2008 (structure data deposition date)
AuthorsPetit-Topin, I. / Turque, N. / Fagart, J. / Fay, M. / Ulmann, A. / Gainer, E. / Rafestin-Oblin, M.E.
External linksMol. Pharmacol. / PubMed:19289570
MethodsX-ray diffraction
Resolution2.26 Å
Structure data

PDB-3d90:
Crystal structure of the human progesterone receptor ligand-binding domain bound to levonorgestrel
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

Chemicals

ChemComp-NOG:
13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / progesterone receptor / steroid receptor / nuclear receptor / transcription factor / women health / contraception / Alternative splicing / DNA-binding / Lipid-binding / Metal-binding / Nucleus / Phosphoprotein / Polymorphism / Receptor / Steroid-binding / Transcription regulation / Zinc / Zinc-finger

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