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Structure paper

TitleInteractions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 7737-7743, Year 2008
Publish dateMay 21, 2008 (structure data deposition date)
AuthorsBarinka, C. / Byun, Y. / Dusich, C.L. / Banerjee, S.R. / Chen, Y. / Castanares, M. / Kozikowski, A.P. / Mease, R.C. / Pomper, M.G. / Lubkowski, J.
External linksJ. Med. Chem. / PubMed:19053759
MethodsX-ray diffraction
Resolution1.54 - 1.75 Å
Structure data

PDB-3d7d:
A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCFBD, a urea-based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-3d7f:
A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCIT, a urea-based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-3d7g:
A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCMC, a urea-based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-3d7h:
A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCIBzL, a urea-based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-FBD:
N-({(1R)-1-carboxy-2-[(4-fluorobenzyl)sulfanyl]ethyl}carbamoyl)-L-glutamic acid

ChemComp-HOH:
WATER

ChemComp-YBY:
N-{[(1S)-1-carboxy-2-(4-hydroxy-3-iodophenyl)ethyl]carbamoyl}-L-glutamic acid

ChemComp-MUD:
N-{[(1R)-1-carboxy-2-(methylsulfanyl)ethyl]carbamoyl}-L-glutamic acid

ChemComp-YC2:
N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amino}pentyl]carbamoyl}-L-glutamic acid

Source
  • homo sapiens (human)
KeywordsHYDROLASE / prostate specific membrane antigen; metallopeptidase; folate hydrolase; glutamate carboxypeptidase II; Naaladase; DCFBD / urea-based inhibitor / Carboxypeptidase / Dipeptidase / Glycoprotein / Membrane / Metal-binding / Metalloprotease / Multifunctional enzyme / Protease / Signal-anchor / Transmembrane / prostate specific membrane antigen; metallopeptidase; folate hydrolase; glutamate carboxypeptidase II; NAALADase / DCIT / prostate specific membrane antigen (PSMA); metallopeptidase; folate hydrolase; glutamate carboxypeptidase II; NAALADase / DCMC / DCIBzL

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