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TitlePotent and selective pyrazole-based inhibitors of B-Raf kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 4692-4695, Year 2008
Publish dateMay 14, 2008 (structure data deposition date)
AuthorsHansen, J.D. / Grina, J. / Newhouse, B. / Welch, M. / Topalov, G. / Littman, N. / Callejo, M. / Gloor, S. / Martinson, M. / Laird, E. ...Hansen, J.D. / Grina, J. / Newhouse, B. / Welch, M. / Topalov, G. / Littman, N. / Callejo, M. / Gloor, S. / Martinson, M. / Laird, E. / Brandhuber, B.J. / Vigers, G. / Morales, T. / Woessner, R. / Randolph, N. / Lyssikatos, J. / Olivero, A.
External linksBioorg. Med. Chem. Lett. / PubMed:18676143
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-3d4q:
Pyrazole-based inhibitors of B-Raf kinase
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-SM5:
(1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase / ATP-binding / Cardiomyopathy / Disease mutation / Metal-binding / Nucleotide-binding / Phorbol-ester binding / Phosphoprotein / Proto-oncogene / Serine/threonine-protein kinase / Zinc-finger

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