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TitlePyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 4237-4241, Year 2008
Publish dateMay 12, 2008 (structure data deposition date)
AuthorsHamblin, J.N. / Angell, T.D. / Ballantine, S.P. / Cook, C.M. / Cooper, A.W. / Dawson, J. / Delves, C.J. / Jones, P.S. / Lindvall, M. / Lucas, F.S. ...Hamblin, J.N. / Angell, T.D. / Ballantine, S.P. / Cook, C.M. / Cooper, A.W. / Dawson, J. / Delves, C.J. / Jones, P.S. / Lindvall, M. / Lucas, F.S. / Mitchell, C.J. / Neu, M.Y. / Ranshaw, L.E. / Solanke, Y.E. / Somers, D.O. / Wiseman, J.O.
External linksBioorg. Med. Chem. Lett. / PubMed:18539455
MethodsX-ray diffraction
Resolution1.75 Å
Structure data

PDB-3d3p:
Crystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-20A:
1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

ChemComp-ARS:
ARSENIC

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PDE / PHOSPHODIESTERASE / cAMP / Alternative splicing / Phosphoprotein / Polymorphism

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