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TitleDiscovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity.
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 6110-6120, Year 2008
Publish dateMay 7, 2008 (structure data deposition date)
AuthorsWang, W.L. / Chai, S.C. / Huang, M. / He, H.Z. / Hurley, T.D. / Ye, Q.Z.
External linksJ. Med. Chem. / PubMed:18785729
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-3d27:
E. coli methionine aminopeptidase with Fe inhibitor W29
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-W29:
4-(3-ethylthiophen-2-yl)benzene-1,2-diol

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE / dinuclear / manganese / iron / peptidase / enzyme-inhibitor complex / metalloenzyme / Aminopeptidase / Cobalt / Metal-binding / Protease

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