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TitleIdentification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 5663-5679, Year 2008
Publish dateMay 1, 2008 (structure data deposition date)
AuthorsHeerding, D.A. / Rhodes, N. / Leber, J.D. / Clark, T.J. / Keenan, R.M. / Lafrance, L.V. / Li, M. / Safonov, I.G. / Takata, D.T. / Venslavsky, J.W. ...Heerding, D.A. / Rhodes, N. / Leber, J.D. / Clark, T.J. / Keenan, R.M. / Lafrance, L.V. / Li, M. / Safonov, I.G. / Takata, D.T. / Venslavsky, J.W. / Yamashita, D.S. / Choudhry, A.E. / Copeland, R.A. / Lai, Z. / Schaber, M.D. / Tummino, P.J. / Strum, S.L. / Wood, E.R. / Duckett, D.R. / Eberwein, D. / Knick, V.B. / Lansing, T.J. / McConnell, R.T. / Zhang, S. / Minthorn, E.A. / Concha, N.O. / Warren, G.L. / Kumar, R.
External linksJ. Med. Chem. / PubMed:18800763
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3d0e:
Crystal structure of human Akt2 in complex with GSK690693
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-G93:
4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE INHIBITOR / human / AKT2 / inhibitor / ATP-binding / Kinase / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase / Transferase

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