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Structure paper

TitleProto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V.
Journal, issue, pagesTo be Published
Publish dateApr 25, 2008 (structure data deposition date)
AuthorsFilippakopoulos, P. / Bullock, A. / Fedorov, O. / Pike, A.C.W. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Knapp, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.15 Å
Structure data

PDB-3cy3:
Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-JN5:
(2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE / oncogene / kinase / serine-threonine / PIM1 / Structural Genomics Consortium / SGC / Alternative initiation / ATP-binding / Manganese / Membrane / Metal-binding / Nucleotide-binding / Nucleus / Phosphoprotein / Proto-oncogene / Serine/threonine-protein kinase / Host-virus interaction / Viral immunoevasion / Virion / Virulence

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