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Structure paper

TitleDiscovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 3224-3229, Year 2008
Publish dateApr 14, 2008 (structure data deposition date)
AuthorsCai, Z.-W. / Wei, D. / Schroeder, G.M. / Cornelius, L.A. / Kim, K. / Chen, X.-T. / Schmidt, R.J. / Williams, D.K. / Tokarski, J.S. / An, Y. ...Cai, Z.-W. / Wei, D. / Schroeder, G.M. / Cornelius, L.A. / Kim, K. / Chen, X.-T. / Schmidt, R.J. / Williams, D.K. / Tokarski, J.S. / An, Y. / Sack, J.S. / Manne, V. / Kamath, A. / Zhang, Y. / Marathe, P. / Hunt, J.T. / Lombardo, L.J. / Fargnoli, J. / Borzilleri, R.M.
External linksBioorg. Med. Chem. Lett. / PubMed:18479916
MethodsX-ray diffraction
Resolution2.3 - 2.5 Å
Structure data

PDB-3cth:
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-3ctj:
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-319:
N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide

ChemComp-HOH:
WATER

ChemComp-320:
2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / RECEPTOR TYROSINE KINASE / SIGNAL TRANSDUCTION / GRB2 / SHC / ATP-BINDING / GLYCOPROTEIN / MEMBRANE / NUCLEOTIDE-BINDING / PHOSPHOPROTEIN / PROTO-ONCOGENE / TRANSMEMBRANE / TYROSINE-PROTEIN KINASE

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