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Structure paper

TitleCrystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.
Journal, issue, pagesNature, Vol. 453, Page 1258-1261, Year 2008
Publish dateMar 18, 2008 (structure data deposition date)
AuthorsCollins, P.J. / Haire, L.F. / Lin, Y.P. / Liu, J. / Russell, R.J. / Walker, P.A. / Skehel, J.J. / Martin, S.R. / Hay, A.J. / Gamblin, S.J.
External linksNature / PubMed:18480754
MethodsX-ray diffraction
Resolution1.9 - 2.538 Å
Structure data

PDB-3ckz:
N1 Neuraminidase H274Y + Zanamivir
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3cl0:
N1 Neuraminidase H274Y + oseltamivir
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3cl2:
N1 Neuraminidase N294S + Oseltamivir
Method: X-RAY DIFFRACTION / Resolution: 2.538 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-ZMR:
ZANAMIVIR / medication, inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-G39:
(3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid / medication, antivirus*YM

Source
  • influenza a virus
KeywordsVIRAL PROTEIN / HYDROLASE / N1 / Neuraminidase / H274Y / Zanamivir / Glycosidase / Membrane / Transmembrane / Virion / oseltamivir / N294S

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