EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.
ジャーナル・号・ページ	Bioorg. Med. Chem. Lett., Vol. 18, Page 2990-2995, Year 2008
掲載日	2008年3月12日 (構造データの登録日)
著者	Antonysamy, S.S. / Aubol, B. / Blaney, J. / Browner, M.F. / Giannetti, A.M. / Harris, S.F. / Hebert, N. / Hendle, J. / Hopkins, S. / Jefferson, E. ...Antonysamy, S.S. / Aubol, B. / Blaney, J. / Browner, M.F. / Giannetti, A.M. / Harris, S.F. / Hebert, N. / Hendle, J. / Hopkins, S. / Jefferson, E. / Kissinger, C. / Leveque, V. / Marciano, D. / McGee, E. / Najera, I. / Nolan, B. / Tomimoto, M. / Torres, E. / Wright, T.
リンク	Bioorg. Med. Chem. Lett. / PubMed:18400495
手法	X線回折
解像度	1.75 - 2.07 Å
構造データ	PDB-3ciz: Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-3cj0: Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3cj2: Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-3cj3: Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-3cj4: Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å PDB-3cj5: Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-SX1: 2-amino-5-bromobenzoic acid / 2-アミノ-5-ブロモ安息香酸 ChemComp-HOH: WATER ChemComp-SX2: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid ChemComp-NI: NICKEL (II) ION ChemComp-SX3: 4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}aniline ChemComp-SX4: 4-bromo-2-{[(2R)-2-(2-chlorobenzyl)pyrrolidin-1-yl]carbonyl}aniline ChemComp-SX5: 4-[(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)amino]-4-oxobutanoic acid ChemComp-SX6: N-(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)-4-morpholin-4-yl-4-oxobutanamide
由来	hepatitis c virus subtype 1b (C型肝炎ウイルス)
キーワード	TRANSFERASE / DRUG DISCOVERY / HCV NS5B / FRAGMENT BASED / Apoptosis / ATP-binding / Capsid protein / Endoplasmic reticulum / Envelope protein / Fusion protein / Glycoprotein / Helicase / Host-virus interaction / Hydrolase / Interferon antiviral system evasion / Lipid droplet / Lipoprotein / Membrane / Metal-binding / Mitochondrion / Multifunctional enzyme / Nucleotide-binding / Nucleotidyltransferase / Nucleus / Oncogene / Palmitate / Phosphoprotein / Protease / Ribonucleoprotein / RNA replication / RNA-binding / RNA-directed RNA polymerase / Secreted / Serine protease / SH3-binding / Thiol protease / Transcription / Transcription regulation / Transmembrane / Viral nucleoprotein / Virion / Acetylation / Cytoplasm / Ubl conjugation / Zinc