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TitlePyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 3168-3172, Year 2008
Publish dateMar 7, 2008 (structure data deposition date)
AuthorsWang, H. / Ruan, Z. / Li, J.J. / Simpkins, L.M. / Smirk, R.A. / Wu, S.C. / Hutchins, R.D. / Nirschl, D.S. / Van Kirk, K. / Cooper, C.B. ...Wang, H. / Ruan, Z. / Li, J.J. / Simpkins, L.M. / Smirk, R.A. / Wu, S.C. / Hutchins, R.D. / Nirschl, D.S. / Van Kirk, K. / Cooper, C.B. / Sutton, J.C. / Ma, Z. / Golla, R. / Seethala, R. / Salyan, M.E. / Nayeem, A. / Krystek, S.R. / Sheriff, S. / Camac, D.M. / Morin, P.E. / Carpenter, B. / Robl, J.A. / Zahler, R. / Gordon, D.A. / Hamann, L.G.
External linksBioorg. Med. Chem. Lett. / PubMed:18485702
MethodsX-ray diffraction
Resolution2.35 Å
Structure data

PDB-3ch6:
Crystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-311:
(3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / 11B-HSD1 / sdr / dehydrogenase / hydroxysteroid / inhibitor

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