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-Structure paper
Title | Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 2669-2674, Year 2008 |
Publish date | Feb 20, 2008 (structure data deposition date) |
Authors | Di Fiore, A. / Pedone, C. / Antel, J. / Waldeck, H. / Witte, A. / Wurl, M. / Scozzafava, A. / Supuran, C.T. / De Simone, G. |
External links | Bioorg. Med. Chem. Lett. / PubMed:18359629 |
Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | PDB-3caj: |
Chemicals | ChemComp-ZN: ChemComp-CL: ChemComp-EZL: ChemComp-MBO: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | LYASE / Protein-inhibitor complex / Disease mutation / Metal-binding |