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-Structure paper
Title | Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography |
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Journal, issue, pages | Mol. Cancer Ther., Vol. 7, Page 2435-2444, Year 2008 |
Publish date | Feb 8, 2008 (structure data deposition date) |
Authors | Woo, L.W.L. / Fischer, D.S. / Sharland, C.M. / Trusselle, M. / Foster, P.A. / Chander, S.K. / Di Fiore, A. / Supuran, C.T. / De Simone, G. / Purohit, A. ...Woo, L.W.L. / Fischer, D.S. / Sharland, C.M. / Trusselle, M. / Foster, P.A. / Chander, S.K. / Di Fiore, A. / Supuran, C.T. / De Simone, G. / Purohit, A. / Reed, M.J. / Potter, B.V.L. |
External links | Mol. Cancer Ther. / PubMed:18723489 |
Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | PDB-3c7p: |
Chemicals | ChemComp-ZN: ChemComp-CL: ChemComp-POF: ChemComp-MBO: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | LYASE / Protein-inhibitor complex / Disease mutation / Metal-binding |