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Structure paper

TitleBinding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 47, Page 4110-4113, Year 2008
Publish dateJun 26, 2007 (structure data deposition date)
AuthorsFreisz, S. / Lang, K. / Micura, R. / Dumas, P. / Ennifar, E.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:18435520
MethodsX-ray diffraction
Resolution1.5 - 2 Å
Structure data

PDB-2qek:
HIV-1 subtype F DIS RNA extended duplex form
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3c3z:
Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to ribostamycin
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-3c44:
Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to paromomycin
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3c5d:
Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to lividomycin
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3c7r:
Crystal Structure of HIV-1 subtype F DIS extended duplex RNA bound to neomycin
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-RIO:
RIBOSTAMYCIN / antibiotic*YM

ChemComp-PAR:
PAROMOMYCIN / Antimicrobial, medication*YM

ChemComp-CL:
Unknown entry

ChemComp-LIV:
(2R,3S,4S,5S,6R)-2-((2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3S,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R / antibiotic*YM

ChemComp-NMY:
NEOMYCIN / antibiotic*YM

KeywordsRNA / HIV RNA Bulged-adenine / HIV-1 / antibiotic / paromomycin / extended duplex / aminoglycoside / lividomycin / neomycin

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