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-Structure paper
Title | Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 2062-2066, Year 2008 |
Publish date | Jan 23, 2008 (structure data deposition date) |
![]() | Isaacs, R.C. / Solinsky, M.G. / Cutrona, K.J. / Newton, C.L. / Naylor-Olsen, A.M. / McMasters, D.R. / Krueger, J.A. / Lewis, S.D. / Lucas, B.J. / Kuo, L.C. ...Isaacs, R.C. / Solinsky, M.G. / Cutrona, K.J. / Newton, C.L. / Naylor-Olsen, A.M. / McMasters, D.R. / Krueger, J.A. / Lewis, S.D. / Lucas, B.J. / Kuo, L.C. / Yan, Y. / Lynch, J.J. / Lyle, E.A. |
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Methods | X-ray diffraction |
Resolution | 1.84 Å |
Structure data | ![]() PDB-3c1k: |
Chemicals | ![]() ChemComp-T15: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / thrombin / thrombin inhibitor complex / Acute phase / Blood coagulation / Cleavage on pair of basic residues / Disease mutation / Gamma-carboxyglutamic acid / Glycoprotein / Hydrolase / Kringle / Protease / Secreted / Serine protease / Zymogen / Protease inhibitor / Serine protease inhibitor / Sulfation / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |