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-Structure paper
Title | Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 2739-2744, Year 2008 |
Publish date | Jan 4, 2008 (structure data deposition date) |
![]() | Wrobleski, S.T. / Lin, S. / Hynes, J. / Wu, H. / Pitt, S. / Shen, D.R. / Zhang, R. / Gillooly, K.M. / Shuster, D.J. / McIntyre, K.W. ...Wrobleski, S.T. / Lin, S. / Hynes, J. / Wu, H. / Pitt, S. / Shen, D.R. / Zhang, R. / Gillooly, K.M. / Shuster, D.J. / McIntyre, K.W. / Doweyko, A.M. / Kish, K.F. / Tredup, J.A. / Duke, G.J. / Sack, J.S. / McKinnon, M. / Dodd, J. / Barrish, J.C. / Schieven, G.L. / Leftheris, K. |
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Methods | X-ray diffraction |
Resolution | 2.4 - 2.59 Å |
Structure data | ![]() PDB-3bv2: ![]() PDB-3bv3: |
Chemicals | ![]() ChemComp-P38: ![]() ChemComp-HOH: ![]() ChemComp-P39: |
Source |
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![]() | TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / KINASE / P38 MAP KINASE / Alternative splicing / ATP-binding / Cytoplasm / Nucleotide-binding / Nucleus / Phosphoprotein |