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Structure paper

TitleRAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex.
Journal, issue, pagesJ. Biol. Chem., Vol. 283, Page 14781-14791, Year 2008
Publish dateDec 21, 2007 (structure data deposition date)
AuthorsFriedmann, D.R. / Wilson, J.J. / Kovall, R.A.
External linksJ. Biol. Chem. / PubMed:18381292
MethodsX-ray diffraction
Resolution2.2 - 2.47 Å
Structure data

PDB-3brd:
CSL (Lag-1) bound to DNA with Lin-12 RAM peptide, P212121
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

PDB-3brf:
CSL (Lag-1) bound to DNA with Lin-12 RAM peptide, C2221
Method: X-RAY DIFFRACTION / Resolution: 2.47 Å

PDB-3brg:
CSL (RBP-Jk) bound to DNA
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-SOR:
sorbitol

Source
  • caenorhabditis elegans (invertebrata)
  • mus musculus (house mouse)
KeywordsDNA BINDING PROTEIN/DNA / protein-DNA complex / signaling / transcription / Notch / DNA-binding / ANK repeat / Developmental protein / Differentiation / EGF-like domain / Glycoprotein / Membrane / Transmembrane / DNA BINDING PROTEIN-DNA COMPLEX / Activator / Alternative splicing / Notch signaling pathway / Nucleus / Repressor / Transcription regulation

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