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Structure paper

TitleDoubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol.
Journal, issue, pagesMol. Cell. Biol., Vol. 28, Page 1915-1923, Year 2008
Publish dateDec 20, 2007 (structure data deposition date)
AuthorsSuino-Powell, K. / Xu, Y. / Zhang, C. / Tao, Y.G. / Tolbert, W.D. / Simons, S.S. / Xu, H.E.
External linksMol. Cell. Biol. / PubMed:18160712
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-3bqd:
Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-DAY:
1-[(1R,2R,3aS,3bS,10aR,10bS,11S,12aS)-1,11-dihydroxy-2,5,10a,12a-tetramethyl-7-phenyl-1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl]-2-hydroxyethanone

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / GLUCOCORTICOID RECEPTOR / deacylcortivazol / SRC1 / nuclear receptor coactivator 1 isoform 1 / DIMER INTERFACE / HORMONE BINDING POCKET / CHARGE CLAMP / COACTIVATOR / Alternative initiation / Alternative splicing / Chromatin regulator / Cytoplasm / Disease mutation / DNA-binding / Lipid-binding / Metal-binding / Nucleus / Phosphoprotein / Polymorphism / Pseudohermaphroditism / Steroid-binding / Transcription / Transcription regulation / Ubl conjugation / Zinc / Zinc-finger / Acyltransferase / Chromosomal rearrangement / Proto-oncogene / Transferase

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