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Title6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor.
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 5856-5860, Year 2008
Publish dateDec 6, 2007 (structure data deposition date)
AuthorsCruz, L.A. / Estebanez-Perpina, E. / Pfaff, S. / Borngraeber, S. / Bao, N. / Blethrow, J. / Fletterick, R.J. / England, P.M.
External linksJ. Med. Chem. / PubMed:18754610
MethodsX-ray diffraction
Resolution1.87 Å
Structure data

PDB-3bki:
Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

Chemicals

ChemComp-FQX:
[1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsTRANSPORT PROTEIN / AMPA receptor / ANQX / quinoxaline-2 / 3-diones / Alternative splicing / Cell junction / Endoplasmic reticulum / Glycoprotein / Ion transport / Ionic channel / Lipoprotein / Membrane / Palmitate / Phosphoprotein / Postsynaptic cell membrane / RNA editing / Synapse / Transmembrane / Transport

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