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-Structure paper
Title | 7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 403-413, Year 2012 |
Publish date | Nov 29, 2007 (structure data deposition date) |
Authors | Huber, K. / Brault, L. / Fedorov, O. / Gasser, C. / Filippakopoulos, P. / Bullock, A.N. / Fabbro, D. / Trappe, J. / Schwaller, J. / Knapp, S. / Bracher, F. |
External links | J. Med. Chem. / PubMed:22136433 |
Methods | X-ray diffraction |
Resolution | 1.24 - 2.1 Å |
Structure data | PDB-3bhy: PDB-3cxw: PDB-3cy2: |
Chemicals | ChemComp-CL: ChemComp-7CP: ChemComp-HOH: ChemComp-MB9: ChemComp-EDO: |
Source |
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Keywords | TRANSFERASE / Death Associated Kinase / DAPK3 / ZIP kinase / ZIPK / DAP kinase 3 / DAP like kinase / Dlk / Structural Genomics Consortium / SGC / Apoptosis / ATP-binding / Chromatin regulator / Nucleotide-binding / Nucleus / Serine/threonine-protein kinase / oncogene / kinase / serine-threonine / PIM1 / Alternative initiation / Manganese / Membrane / Metal-binding / Phosphoprotein / Proto-oncogene / Host-virus interaction / Viral immunoevasion / Virion / Virulence |