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-Structure paper
Title | Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. |
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Journal, issue, pages | J. Med. Chem., Vol. 51, Page 1459-1463, Year 2008 |
Publish date | Nov 23, 2007 (structure data deposition date) |
Authors | Beich-Frandsen, M. / Pickering, D.S. / Mirza, O. / Johansen, T.N. / Greenwood, J. / Vestergaard, B. / Schousboe, A. / Gajhede, M. / Liljefors, T. / Kastrup, J.S. |
External links | J. Med. Chem. / PubMed:18269227 |
Methods | X-ray diffraction |
Resolution | 1.95 - 2.27 Å |
Structure data | PDB-3bft: PDB-3bfu: |
Chemicals | ChemComp-S2P: ChemComp-ZN: ChemComp-NA: ChemComp-CL: ChemComp-CAC: ChemComp-HOH: ChemComp-R2P: |
Source |
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Keywords | MEMBRANE PROTEIN / AMPA receptor / GluR2 / ligand-binding core / agonist / (S)-TDPA / Cell junction / Endoplasmic reticulum / Glycoprotein / Ion transport / Ionic channel / Lipoprotein / Membrane / Palmitate / Phosphoprotein / Postsynaptic cell membrane / RNA editing / Synapse / Transmembrane / Transport / (R)-TDPA / Alternative splicing |