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TitleIdentification of a potent synthetic FXR agonist with an unexpected mode of binding and activation.
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 105, Page 5337-5342, Year 2008
Publish dateNov 19, 2007 (structure data deposition date)
AuthorsSoisson, S.M. / Parthasarathy, G. / Adams, A.D. / Sahoo, S. / Sitlani, A. / Sparrow, C. / Cui, J. / Becker, J.W.
External linksProc. Natl. Acad. Sci. Usa / PubMed:18391212
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-3bej:
Structure of human FXR in complex with MFA-1 and co-activator peptide
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-YT3:
YTTRIUM (III) ION

ChemComp-MUF:
(8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION REGULATOR / FXR / BAR / NR1H4 / bile acid receptor / NHR / nuclear receptor / Activator / Alternative splicing / DNA-binding / Metal-binding / Nucleus / Repressor / Transcription / Transcription regulation / Zinc / Zinc-finger / Acyltransferase / Chromosomal rearrangement / Phosphoprotein / Polymorphism / Proto-oncogene / Transferase / Ubl conjugation / transcription-transferase COMPLEX

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