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-Structure paper
Title | Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 1451-1456, Year 2009 |
Publish date | Nov 12, 2007 (structure data deposition date) |
![]() | Zhang, H. / Ryono, D.E. / Devasthale, P. / Wang, W. / O'Malley, K. / Farrelly, D. / Gu, L. / Harrity, T. / Cap, M. / Chu, C. ...Zhang, H. / Ryono, D.E. / Devasthale, P. / Wang, W. / O'Malley, K. / Farrelly, D. / Gu, L. / Harrity, T. / Cap, M. / Chu, C. / Locke, K. / Zhang, L. / Lippy, J. / Kunselman, L. / Morgan, N. / Flynn, N. / Moore, L. / Hosagrahara, V. / Kadiyala, P. / Xu, C. / Doweyko, A.M. / Bell, A. / Chang, C. / Muckelbauer, J. / Zahler, R. / Hariharan, N. / Cheng, P.T. |
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Methods | X-ray diffraction |
Resolution | 2.27 Å |
Structure data | ![]() PDB-3bc5: |
Chemicals | ![]() ChemComp-ZAA: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSCRIPTION / ligand-binding domain / nuclear hormone receptor / transcription factor / Activator / Alternative splicing / Diabetes mellitus / Disease mutation / DNA-binding / Metal-binding / Nucleus / Obesity / Phosphorylation / Polymorphism / Transcription regulation / Zinc / Zinc-finger |