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TitleExploring inhibitor binding at the S' subsites of cathepsin L
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 1361-1368, Year 2008
Publish dateNov 12, 2007 (structure data deposition date)
AuthorsChowdhury, S.F. / Joseph, L. / Kumar, S. / Tulsidas, S.R. / Bhat, S. / Ziomek, E. / Menard, R. / Sivaraman, J. / Purisima, E.O.
External linksJ. Med. Chem. / PubMed:18278855
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-3bc3:
Exploring inhibitor binding at the S subsites of cathepsin L
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-OPT:
S-benzyl-N-(biphenyl-4-ylacetyl)-L-cysteinyl-N~5~-(diaminomethyl)-D-ornithyl-N-(2-phenylethyl)-L-tyrosinamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / cathepsin L inhibitor binding at the S subsites / Glycoprotein / Lysosome / Protease / Thiol protease / Zymogen

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