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-Structure paper
Title | Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 44-48, Year 2008 |
Publish date | Nov 2, 2007 (structure data deposition date) |
Authors | Bandarage, U.K. / Wang, T. / Come, J.H. / Perola, E. / Wei, Y. / Rao, B.G. |
External links | Bioorg. Med. Chem. Lett. / PubMed:18054488 |
Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | PDB-3b92: |
Chemicals | ChemComp-ZN: ChemComp-440: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / TNF-alpha converting enzyme / aryl-sulfonamide / TACE inhibitors / Alternative splicing / Cleavage on pair of basic residues / Glycoprotein / Membrane / Metal-binding / Metalloprotease / Notch signaling pathway / Phosphorylation / Protease / SH3-binding / Transmembrane / Zinc / Zymogen |