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TitleSynthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors
Journal, issue, pagesJ. Med. Chem., Vol. 55, Page 2960-2969, Year 2012
Publish dateNov 25, 2010 (structure data deposition date)
AuthorsMiyakoshi, H. / Miyahara, S. / Yokogawa, T. / Chong, K.T. / Taguchi, J. / Endoh, K. / Yano, W. / Wakasa, T. / Ueno, H. / Takao, Y. ...Miyakoshi, H. / Miyahara, S. / Yokogawa, T. / Chong, K.T. / Taguchi, J. / Endoh, K. / Yano, W. / Wakasa, T. / Ueno, H. / Takao, Y. / Nomura, M. / Shuto, S. / Nagasawa, H. / Fukuoka, M.
External linksJ. Med. Chem. / PubMed:22404301
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-3ara:
Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-MKH:
1-[3-({(2R)-2-[hydroxy(diphenyl)methyl]pyrrolidin-1-yl}sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHydrolase/Hydrolase inhibitor / Hydrolase / Magnesium Binding / Hydrolase-Hydrolase inhibitor complex

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