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Structure paper

TitleRecognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer
Journal, issue, pagesImmunity, Vol. 31, Page 873-884, Year 2009
Publish dateSep 20, 2009 (structure data deposition date)
AuthorsKang, J.Y. / Nan, X. / Jin, M.S. / Youn, S.-J. / Ryu, Y.H. / Mah, S. / Han, S.H. / Lee, H. / Paik, S.-G. / Lee, J.-O.
External linksImmunity / PubMed:19931471
MethodsX-ray diffraction
Resolution2.4 - 2.9 Å
Structure data

PDB-3a79:
Crystal structure of TLR2-TLR6-Pam2CSK4 complex
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-3a7b:
Crystal structure of TLR2-Streptococcus Pneumoniae lipoteichoic acid complex
Method: X-RAY DIFFRACTION / Resolution: 2.53 Å

PDB-3a7c:
Crystal structure of TLR2-PE-DTPA complex
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-PXS:
(2S)-propane-1,2-diyl dihexadecanoate

ChemComp-LTC:
(2S)-1-({3-O-[2-(acetylamino)-4-amino-2,4,6-trideoxy-beta-D-galactopyranosyl]-alpha-D-glucopyranosyl}oxy)-3-(heptanoyloxy)propan-2-yl (7Z)-pentadec-7-enoate

ChemComp-HOH:
WATER

ChemComp-PDK:
(10S,13R)-3-{2-[{2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino]ethyl}-10-hydroxy-5,16-dioxo-13-(tetradecanoyloxy)-9,11,15-trioxa-3,6-diaza-10-phosphanonacosan-1-oic acid 10-oxide

ChemComp-LU:
Unknown entry

Source
  • mus musculus (house mouse)
  • eptatretus burgeri (inshore hagfish)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / Toll-like Receptor / diacyl lipopeptide / innate immunity / Leucine Rich Repeat / Cell membrane / Cytoplasmic vesicle / Disulfide bond / Glycoprotein / Immune response / Inflammatory response / LEUCINE-RICH REPEAT / Membrane / Receptor / Transmembrane / Phosphoprotein / lipoteichoic acid / PE-DTPA

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